Teaching TEI: The Need for TEI by Example

The Text Encoding Initiative (TEI)1 has provided a complex and comprehensive system of provisions for scholarly text encoding. Although a major focus of the ‘digital humanities’ domain, and despite much teaching effort by the TEI community, there is a lack of teaching materials available, which would encourage the adoption of the TEI's recommendations and the widespread use of its text encoding guidelines in the wider academic community. This article describes the background, plans, and aims of the TEI by Example project, and why we believe it is a necessary addition to the materials currently provided by the TEI itself. The teaching materials currently available are not suited to the needs of self directed learners, and the development of stand alone, online tutorials in the TEI are an essential addition to the extant resources, in order to encourage and facilitate the uptake of TEI by both individuals and institutions

Event-based visual guidance inspired by honeybees in a 3D tapered tunnel

International audience— In view of neuro-ethological findings on honeybees and our previously developed vision-based autopilot, in-silico experiments were performed in which a " simulated bee " was make to travel along a doubly tapering tunnel including for the first time event-based controllers. The " simulated bee " was equipped with: • a minimalistic compound eye comprising 10 local motion sensors measuring the optic flow magnitude, • two optic flow regulators updating the control signals whenever specific optic flow criteria changed, • and three event-based controllers taking into account the error signals, each one in charge of its own translational dynamics. A MORSE/Blender based simulator-engine delivered what each of 20 " simulated photoreceptors " saw in the tunnel lined with high resolution natural 2D images. The " simulated bee " managed to travel safely along the doubly tapering tunnel without requiring any speed or distance measurements, using only a Gibsonian point of view, by: • concomitantly adjusting the side thrust, vertical lift and forward thrust whenever a change was detected on the optic flow-based signal errors, • avoiding collisions with the surface of the doubly tapering tunnel and decreasing or increasing its speed, depending on the clutter rate perceived by motion sensors

Conservation of diatom biodiversity: issues and prospects

The diatoms are microscopic unicellular plants, which in spite of their tiny size (normally within the range of 0.01-0.1 mm) play an enormous role in the functioning of the biosphere. Their contribution to the global production of organic matter created on Earth through photosynthesis is estimated as 20-25%. Very recently, the results of sensitive, fine-grained taxonomical, biological and biogeographical studies have provided strong evidence that the widely accepted dogma that microorganisms are predominantly cosmopolitan does not apply in case of the diatoms. Many diatom species may be endemics and some of them seem to be restricted to a small geographical area, which makes conservation of diatoms a significant issue. It is time to realise that efforts to develop realistic conservation strategies for aquatic environments, both at the local and global scale should include the diatoms and possibly also other groups of microorganisms. Some ways of how the diatoms could be involved in this process are presented for discussion

Endothelium-derived Vasoactive Factors and Hypertension: Possible Roles in Pathogenesis and as Treatment Targets

Endothelial cells regulate vascular tone by releasing various contracting and relaxing factors including nitric oxide (NO), arachidonic acid metabolites (derived from cyclooxygenases, lipoxygenases, and cytochrome P450 monooxygenases), reactive oxygen species, and vasoactive peptides. Additionally, another pathway associated with the hyperpolarization of the underlying smooth muscle cells plays a predominant role in resistance arteries. Endothelial dysfunction is a multifaceted disorder, which has been associated with hypertension of diverse etiologies, involving not only alterations of the L-arginine NO-synthase–soluble guanylyl cyclase pathway but also reduced endothelium-dependent hyperpolarizations and enhanced production of contracting factors, particularly vasoconstrictor prostanoids. This brief review highlights these different endothelial pathways as potential drug targets for novel treatments in hypertension and the associated endothelial dysfunction and end-organ damage

Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice

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Liquid Chromatography Electron Capture Dissociation Tandem Mass Spectrometry (LC-ECD-MS/MS) versus Liquid Chromatography Collision-induced Dissociation Tandem Mass Spectrometry (LC-CID-MS/MS) for the Identification of Proteins

Electron capture dissociation (ECD) offers many advantages over the more traditional fragmentation techniques for the analysis of peptides and proteins, although the question remains: How suitable is ECD for incorporation within proteomic strategies for the identification of proteins? Here, we compare LC-ECD-MS/MS and LC-CID-MS/MS as techniques for the identification of proteins.Experiments were performed on a hybrid linear ion trap–Fourier transform ion cyclotron resonance mass spectrometer. Replicate analyses of a six-protein (bovine serum albumin, apo-transferrin,lysozyme, cytochrome c, alcohol dehydrogenase, and β-galactosidase) tryptic digest were performed and the results analyzed on the basis of overall protein sequence coverage and sequence tag lengths within individual peptides. The results show that although protein coverage was lower for LC-ECDMS/MS than for LC-CID-MS/MS, LC-ECD-MS/MS resulted in longer peptide sequence tags,providing greater confidence in protein assignment

Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment

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